i'm marianne rafferty. now, back to fox files. weather. >> what does a famous hollywood actress, a tough fearless hockey player, and a woman who grew up in the 1930s have in common? they are all in the center of a medical mystery that may effect 3 million people in the united states. we begin with jennifer esposito's story. >> you are a new york girl all of the way. >> born in brooklyn and raised in staten island. i wanted to come to the city and start my acting career. >> growing up in a middle class family actress jennifer esposito caught everyone's attention with television shows like "spin city" to award winning films like "crash" and most recent work on cbs's "blue blood." while her hole skood sthollywoo was riding she suffered from an illness that slowly debilitated her. >> when did you realize something was wrong? >> when i was a teenager i had p problems with getting colds and infections sinus infections all of the time. so much so i was hospitalized with monday no. >> she would suffer and as a family we would say okay, sh